早期子宫颈癌前哨淋巴结活检技术的临床应用及研究进展

Clinical application and research advances of sentinel lymph node biopsy technology in early-stage cervical cancer

  • 摘要: 子宫颈癌(cervical cancer,CC)是严重威胁女性健康的常见妇科恶性肿瘤。根治性子宫切除联合系统性盆腔淋巴结清扫术(pelvic lymphadenectomy,PLND)是早期患者的标准术式,然而该术式对占多数的淋巴结阴性患者而言,不仅无法获益,还会导致淋巴结水肿等长期并发症,严重影响患者生存质量。前哨淋巴结活检(sentinel lymph node biopsy,SLNB)技术通过应用特异性示踪剂精准定位并切除前哨淋巴结进行病理评估,能够准确判断区域淋巴结状态,旨在使阴性患者免于系统性清扫,从而显著降低手术创伤与并发症风险。本文系统综述了早期CC的SLNB常用示踪方法、临床应用、研究进展及实施挑战,以期为该技术在我国的规范化应用提供理论依据。

     

    Abstract: Cervical cancer is a common gynecological malignancy and a serious threat to women’s health. Although radical hysterectomy with systematic pelvic lymphadenectomy (PLND) remains the standard treatment for early-stage disease, most patients are ultimately be found to be node-negative. For these patients, PLND offers no survival benefit, but causes lifelong morbidities, including lymphedema, which severely impairs quality of life. Sentinel lymph node biopsy (SLNB) uses specific tracers to precisely identify and resect first-draining nodes for histopathological assessment. This technique can accurately determine regional nodal status while sparing node-negative women from comprehensive lymph node dissection, thereby markedly reducing surgical trauma and complication rates. This review systematically summarizes commonly employed tracing methods, clinical applications, recent advances, and implementation challenges of SLNB in early cervical cancer, with the aim of providing an evidence-based framework for its standardized adoption in China.

     

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