Abstract: Objective: To explore the clinical value of stereotactic wire-localized biopsy (SWLB) in digital mammography in the detection of microcalcification of the breast.Methods:A total of 45patients with nonpal -pable breast lesions which were positive for microcalcification by mammography but could not be detected clinically underwent SWLB. Their mammography findings were analyzed in detail with pathology. Results: Among the 45cases, 13cases (28.9% ) had malignant lesions including ductal carcinoma in situ in3 cases (20.1%), ductal carcinoma in situ with microinvasion in 4 cases (30.8%), invasive ductal carcinoma in5 cases (38.5%) and intraductal papillary carcinoma in1 case ( 7.7%). Thirty-two cases (71.1%) had benign lesions,2 cases (6.3%) of which were severe atypical hyperplasia.Conclusion:SWLB can accurately guide the surgical excision of nonpalpable breast microcalcification lesions and diagnose microcalcifications exactly, which is helpful for increasing the detection rate of early-stage breast cancer.