肝细胞肝癌中微血管密度及MMP-2 和MMP-9 的表达与术后转移及预后的关系*

The Microvessel Density and Expression of MMP- 2 and MMP- 9 in Hepatocellular Carcinoma and Their Correlation with Metastasis and Prognosis

摘要: 目的：探讨微血管密度（MVD）、基质金属蛋白酶-2（MMP-2）和MMP-9 在肝细胞肝癌转移中的作用及其各自和预后的相关性。方法：以石蜡包埋组织切片，免疫组化SP法染色分别检测97例肝细胞肝癌MVD和MMP-2、MMP-9 表达的情况，其中复发与转移组49例，非复发与转移组48例。结果：转移组MVD高于无转移组（P=0.015），转移组MMP-2 和MMP-9 表达高于无发转移组（P=0.009，P=0.043），差异具有统计学意义。结论：MVD增高、MMP-2 和MMP-9 过度表达可能与肝细胞肝癌转移、不良生存预后存在相关性。

Abstract: Objective:To investigate the effect of microvessel density and expression of MMP- 2 and MMP- 9 on the me-tastasis of hepatocellular carcinoma and their correlation with patients ’prognosis. Methods:Immunohistochemistry (SP) was employed to detect MVD and expression of MMP-2 and MMP- 9 in 97samples of hepatocellular carcinoma. There were 49cases with metastasis and 48cases with no metastasis. Results: The abnormal MVD and expression of MMP-2 and MMP- 9 in cases with metastasis were higher than those in cases with no metastasis (P=0.015 ; P=0.009 ). Conclusion: Abnomal MVD and expression of MMP- 2 and MMP- 9 may play an important role in the metastasis of hepatocellular carci-noma and indicate poor prognosis.