卵巢浆液性肿瘤PTTG的表达与MMP-2 及VEGF的关系*

PTTG Expression and Its Relationship with MMP-2 and VEGF in Ovarian Serous Tumor

    摘要
  • 摘要: 目的：研究垂体肿瘤转化基因（PTTG）蛋白、基质金属蛋白酶-2（MMP-2）、血管内皮生长因子（VEGF）在卵巢浆液性肿瘤中的表达及其相关性，探讨PTTG在卵巢浆液性肿瘤恶性转化中的作用及与肿瘤侵袭性的关系。方法：运用免疫组织化学的方法检测30例卵巢浆液性囊腺瘤、21例卵巢交界性浆液性囊腺瘤、30例卵巢浆液性囊腺癌原发灶和网膜转移灶中PTTG、MMP-2及VEGF的表达水平。结果：1）PTTG在卵巢浆液性肿瘤各分组中表达差异有统计学意义（P<0.01），其中交界性浆液性囊腺瘤组的表达高于浆液性囊腺瘤组（P<0.01），浆液性囊腺癌原发灶组表达高于交界性组（P<0.01），浆液性囊腺癌网膜转移灶组表达高于原发灶组（P<0.05）；2）MMP-2 在浆液性囊腺癌原发灶组及交界性浆液性囊腺瘤组中的表达高于浆液性囊腺瘤组（P<0.01），在浆液性囊腺癌网膜转移灶中的表达高于原发灶组（P<0.05）；3）VEGF在浆液性囊腺癌原发灶组及交界性浆液性囊腺瘤组中的表达高于浆液性囊腺瘤组（P<0.05），在浆液性囊腺癌网膜转移灶组与原发灶组间表达差异无统计学意义（P>0.05）；4）PTTG、MMP-2和VEGF三者的表达水平呈正相关（P<0.01）。 结论：PTTG表达程度随卵巢浆液性肿瘤恶性程度及侵袭性的增加而升高，PTTG可能参与了卵巢浆液性肿瘤恶性转化过程并且通过上调MMP-2 及VEGF的表达在肿瘤侵袭转移中发挥重要作用。

     

    Abstract: Objective: To explore the expression of pituitary tumor transforming gene (PTTG), matrix metalloprotein -ase- 2 (MMP- 2) and vascular endothelial growth factor (VEGF) in ovarian serous tumor, and to investigate the function of PTTG in malignant transformation, invasiveness and metastasis of ovarian serous tumor. Methods:The expression of PTTG, MMP- 2 and VEGF was examined with immunohistochemistry in 30tissue samples of ovarian serous cystadenoma, 21 tissue samples of ovarian borderline serous cystadenoma and 30tissue samples of ovarian serous cystadenocarcino-ma including primary and metastatic sites. Results: There was a significant difference in the expression of PTTG among the three groups of ovarian serous tumor ( P<0.01). PTTG expression in ovarian borderline serous cystadenoma was higher than that in ovarian serous cystadenoma (P<0.01). The primary site of ovarian serous cystadenocarcinoma showed higher PTTG expression than ovarian borderline serous cystadenoma (P<0.01). Compared with the primary site, the metastatic site of ovarian serous cystadenocarcinoma showed higher PTTG expression (P<0.05). The expression of MMP-2 in ovari -an serous cystadenocarcinoma primary site and ovarian borderline serous cystadenoma was higher than in ovarian serous cystadenoma ( P<0.01). MMP- 2 expression in the ovarian serous cystadenocarcinoma metastatic site was higher than in pri-mary site ( P<0.05). VEGF expression in the ovarian serous cystadenocarcinoma primary site and ovarian borderline se -rous cystadenoma was higher than in ovarian serous cystadenoma ( P<0.05). No significant difference was found in VEGF expression between the primary site and metastatic site of ovarian serous cystadenocarcinoma ( P>0.05). The expression of PTTG was positively correlated with MMP- 2 and VEGF in ovarian serous tumor. Conclusion:The expression level of PTTG was correlated with the degree of malignancy and invasiveness. PTTG may participate the malignant transformation and may play an important role in the invasiveness and metastasis of ovarian serous tumor by up-regulating MMP-2 and VEGF expression.

     

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