子宫颈癌腹主动脉旁淋巴结转移的诊断及治疗

Diagnosis and Treatment of Para-aortic Lymph Node Metastasis of Cervical Cancer

  • 摘要: 子宫颈癌在女性恶性生殖系统肿瘤中的发生率居于首位,其中腹主动脉旁淋巴结(para-aortic lymph node PALN)转移与宫颈癌的治疗、预后密切相关。宫颈癌的淋巴转移途经多为宫颈旁、宫旁转移到闭孔、髂内外,再转移到髂总、骶前,最终汇集于腹主动脉旁淋巴结及(或)转移至锁骨上或腹股沟深淋巴结的阶梯式转移,但也存在不经过盆腔淋巴结的跳跃式转移。肿瘤的临床分期、有无宫旁浸润、盆腔淋巴结转移情况以及治疗前SCC 值等被认为是影响腹主动脉旁淋巴结转移的重要因素。术前评价淋巴结是否转移大多通过影像学诊断,CT通过显示淋巴结在横断面上的最大直径以及淋巴结内部密度改变来评价淋巴结是否转移,是目前应用最广泛的诊断方法,但其敏感性及准确性均低于PET 。肿大的腹主动脉旁淋巴结可以手术切除,特别是腹膜外腹主动脉旁淋巴结切除术以及腹腔镜下腹主动脉旁淋巴结切除术,由于其创伤小、对术后放疗影响小等优点逐渐发展起来,既能诊断,同时也有重要的治疗价值。腹主动脉旁淋巴结是宫颈癌治疗后最常见的复发部位之一,但被认为更多是局部病变,对复发淋巴结区域采取积极治疗仍可明显改善生存率。但初治时即存在腹主动脉旁淋巴结转移者,患者往往同时有远处转移或会在较短时间内出现远处转移,预后差。

     

    Abstract: Cervical cancer is the most common cancer in the female genital system. Para-aortic lymph nodes (PALN) involvement is closely related with treatment and prognosis. Cervical cancer often metastasize to pericervical and parame -trial nodes, internal and external iliac nodes, obturator nodes, and then to common iliac nodes and pre-sacral nodes and fi -nally to PALN and (or) supraclavicular or inguinal lymph nodes. A few patients with cervical cancer had distant lymph nodes metastasis without pelvic lymph nodes involvement. Staging, parametrial invasion and value of Squamous Cell Carcinoma Antigen (SCC) are considered as high risk factors for PALN metastasis. Computed Tomography (CT) is the mostly used im-aging examination to evaluate the lymph nodes metastasis of cervical cancer through measuring the largest diameter of the enlarged lymph nodes and observing the density change of internal part of the lymph nodes. Positron Emission Tomog -raphy (PET) is more sensitive and accurate than CT scan. Surgery is the main management for enlarged PALN not only for therapy but also for diagnosis. Dissection of abdominal extraperitoneal para-aortic lymph nodes and laparoscopical aortic lymph nodes is used widely because of its advantages such as less trauma and less put-off for post-surgical radiation. PALN is one of most common recurrence site of cervical cancer after treatment. Active treatment for recurrence in lymph nodes can improve patient survival.

     

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