Abstract: Objective:To study the expression of C-Met, VEGF and its receptor KDR in colorectal carcinoma and their relationship with the prognosis of colorectal cancer. Methods:The expression of C-Met, VEGF and its receptor KDR in colorectal carcinoma tissue ( 60samples) were detected with immunohistochemisty. Follow-up was performed and5-year survival rate was analyzed.Results: The positive rate of C-Met, VEGF and its receptor KDR expression in colorectal carci-noma tissue was 43.3%,61.7% and 68.3%, respectively. The expression of C-Met, VEGF and its receptor KDR in colorec-tal carcinoma tissue was closely associated with the depth of invasion, lymph node metastasis and Dukes stage ( P<0.05), but was not related to patients' age or sex ( P>0.05). The five-year survival rate of patients with positive expression of C-Met, VEGF and its receptor KDR were42.3%,43.2% and 51.2%. The five-year survival rates of patients without C-Met, VEGF and its receptor KDR were 73.5% ,87.0% and 78.9% , respectively. The difference was statistically significant ( P<0.05). Cox regression analysis showed that C-Met, VEGF and its receptor KDR were risk factors. Combined detection of C-Met, VEGF and its receptor KDR provided useful information for prognosis prediction of colorectal cancer patients.Conclusion: The expression of C-Met, VEGF and its receptor KDR in colorectal carcinoma is correlated with tumor occurrence and development. Positive expression of the three indicies indicate poor prognosis.