Abstract: To investigate the effect of NE regimen to xenotransplant breast cancer, which has been erroneously treated by TE regimen，and to detect the expression of surviving mRNA, BCRP mRNA, and HER-2 mRNA. Methods: The breast cancer cells were inoculated into nude mice, which were grouped and treated with 0.9% NaCl, low dose and standard dose ( NVB combination with EPI ). The excised tumor masses were detected on the 21st day after administration by reverse transcription polymerase chain reaction ( RT-PCR ) and Western blot to investigate the expression of surviving mRNA, BCRP mRNA, and HER-2 mRNA. Results: The standard dose group showed the most significant effect in all groups ( 74.5% ).  The expression of surviving mRNA, BCRP mRNA, and HER-2 mRNA in the standard dose group was lower than that in the low dose group ( P < 0.05 ). Conclusion: NE regimen was effective to most patients who were erroneously treated by TE regimen. It was related to the down-regulated expression of survivin mRNA, BCRP mRNA, and HER-2 mRNA.