Abstract: Breast cancer is a malignant tumor, which can be commonly found in females.  Hormonal treatment has become one of the major therapies for breast cancer, however only 33% to 50% of breast cancer cases can effectively respond to hormonal treatment. The failure in treatment could be related to the high concentration of estrogens in the tumor. Local biosynthesis of estrogens is believed to play a very important role in the high concentration of estrogen in breast carcinoma and may be more important than circulating estrogens to the occurrence and development of breast cancer. Local biosynthesis of estrogens is mainly influenced by two pathways in breast carcinoma, namely, sulfatase and aromatase pathways. Steroid Sulfatase ( STS ) and Estrogen Sulfotransferase ( EST ) are two significant enzymes that are associated with the synthesis and metabolism of estrogen in the sulfatase pathway, whereas Aromatase ( AROM ) is important in aromatase pathway. The current paper reviews the study of hormonal treatment for breast carcinoma.