联合检测CA125 CA199和CEA对卵巢癌诊断价值的Meta分析

Combined Detection of CA125, CA19-9, and CEA in the Diagnosis of Ovarian Cancer: A Meta Analysis

    摘要
  • 摘要:
      目的  评价联合检测血清CA125、CA199、CEA在卵巢癌诊断中的价值。
      方法  计算机检索Pubmed、CBMdisc、CNKI、维普等数据库, 收集关于卵巢癌诊断中联合检测CA125、CA199、CEA的文献。采用Meta-DiSc 14.0、Stata10.0进行Meta分析。
      结果  按照统一的纳入标准和排除标准获得12篇文献。结果显示在卵巢癌诊断中, 联合检测CA 125、CA199、CEA的灵敏度(SE)、特异度(SP)、诊断比值比(DOR)、SROC曲线下面积(AUC)、Q指数分别为0.90(0.88~0.93)、0.83(0.80~0.86)、39.75(22.58~69.97)、0.953、0.895。单独检测CA125的SE、SP、DOR、AUC、Q指数分别为0.73(0.69~0.77)、0.88(0.86~0.91)、17.45(9.95~30.48)、0.804、0.739。两种检测方式的诊断效能比较差异有统计学意义(Z=4.859, P < 0.05)。
      结论  卵巢癌的临床辅助诊断中, 与单独检测CA125比较, 联合检测CA125、CA199、CEA的判别能力较强、准确率较高, 可提高诊断效能。

     

    Abstract:
      Objective  The current work aims to evaluate the importance of combined detection of the tumor markers CA125, CA19-9, and CEA in the diagnosis of ovarian cancer.
      Methods  A computerized literature search was carried out in the databases of Pubmed, CBMdisc, CNKI, and VIP, among others, to collect articles regarding the diagnostic value of combined detection of the cancer markers CA125, CA19-9, and CEA in the diagnosis of ovarian cancer.Meta DiSc14.0 and Stata10.0 software were used to conduct the meta-analysis.
      Results  A total of 12 literatures were obtained in the current study with the unified inclusion and exclusion criteria.The results showed that the sensitivity(SE), specificity(SP), diagnostic odds ratio(DOR), area under curve of SROC curve(AUC), and Q* index of the tumor markers CA125, CA19-9, and CEA were 0.90(0.88-0.93), 0.83(0.80-0.86), 39.75(22.58-69.97), 0.95 and 0.89, respectively, in the diagnosis of ovarian cancer.In contrast, the indices of SE, SP, DOR, AUC, and Q* of the marker CA125 that was detected alone were 0.73(0.69-0.77), 0.88(0.86-0.91), 17.45(9.95-30.48), 0.804, and 0.739 respectively.The result of the Z test has proven that significant differences exist between the two methods in diagnosing ovarian cancer(Z=4.859, P < 0.05).
      Conclusion  The combined detection of CA19-9, CA125, and CEA in the clinically auxiliary diagnosis of ovarian cancer may provide more competent and valuable laboratory proof compared with solitary detection of CA125.

     

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