BCL-6 P-gp在初诊弥漫大B细胞淋巴瘤中的表达及与IPI指数的相关性研究

Expression of BCL-6 and P-gp in Diffuse Large B-cell Lymphoma and Its Relationship with the IPI Index

    摘要
  • 摘要:
      目的  通过免疫组化方法检测初诊弥漫大B细胞淋巴瘤（DLBCL）患者活检淋巴组织BCL-6、P-gp的表达，探讨初诊DLBCL患者上述指标表达的临床意义以及与IPI指数间的相关性。
      方法  收集福建省立医院病理科存档的2006年10月~2010年10月，首次确诊DLBCL且接受化疗（CHOP或R-CHOP方案）≥2个疗程患者标本34例（其中27例完成6个疗程化疗），检测BCL-6、P-gp的表达。入选病例根据国际预后指数（IPI）进行评分，将评分结果分别与所检测指标的表达结果进行相关性分析；将患者2、6个疗程化疗疗效分别与IPI评分、BLL-6、P-gp表达进行分析。
      结果  BCL-6、P-gp高表达与IPI评分密切相关，其中BCL-6高表达与IPI评分呈负相关，P-gp阳性表达与IPI评分呈正相关；2个疗程化疗疗效与IPI评分无相关性，与BCL-6高表达呈负相关，与P-gp呈正相关；6个疗程化疗疗效与BCL-6阳性表达呈负相关，与P-gp呈正相关。
      结论  在初诊DLBCL患者中，BCL-6高表达与良好预后相关，P-gp高表达则提示预后不良。

     

    Abstract:
      Objective  To investigate the expression of BCL-6 and P-gp in DLBCL and to explore the relationship of BCL-6 and P-gp with the IPI index.
      Methods  A total of 34 samples were obtained from the pathology department of Fujian provincial hospital. These samples were collected from DLBCL patients treated with more than two therapeutic courses. BCL-6 and P-gp expression, as well as their relationship with the patient prognosis were examined.
      Results  BCL-6 and P-gp were closely related with the IPI score. BCL-6 was negatively while P-gp was positively correlated with the IPI score. The curative effects of two therapeutic courses had no relation ship with the IPI score but had a negative correlation with BCL-6 and a positive correlation with P-gp. The curative effects of six therapeutic courses had a negative correlation with BCL-6 and positive correlations with the IPI score and P-gp.
      Conclusion  In DLBCL patients, high BCL-6 expression indicates better prognosis and high P-gp expression indicates poor prognosis.

     

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