IFT20蛋白在不同肿瘤组织中表达的研究

Expression of Intraflagellar Transport 20 Protein in Tumor Tissues

    摘要
  • 摘要:
      目的  探讨IFT20（Intraflagellar Transport，IFT）蛋白在人卵巢癌、肺癌、胰腺癌、小肠癌、前列腺癌、骨癌、胃癌和乳腺癌癌组织和癌旁组织的表达分布情况，为人类肿瘤的诊断和治疗寻找新的靶点。
      方法  采用免疫组织化学方法，研究IFT20蛋白在人的八种癌组织和癌旁组织的表达。
      结果  结果发现，IFT20蛋白在卵巢癌组织中大量表达，在卵巢癌癌旁组织低量表达。IFT20蛋白在小肠癌，胃癌和乳腺癌组织中中量表达，在小肠癌，胃癌和乳腺癌癌旁组织中低量表达。IFT20蛋白在胰腺癌，骨癌，肺癌癌组织中低量表达，在胰腺癌、骨癌、肺癌癌旁组织中几乎不表达。IFT20蛋白在前列腺癌组织和癌旁组织中均未见表达。
      结论  实验结果证实，IFT20蛋白可能经过多种途径直接或间接调节卵巢癌、肺癌、胰腺癌、小肠癌、骨癌、胃癌和乳腺癌的发生，发展过程，并且IFT20可能是卵巢癌、肺癌、胰腺癌、小肠癌、骨癌、胃癌和乳腺癌肿瘤药物治疗的潜在靶点。

     

    Abstract:
      Objective  To find a new target for the diagnosis and treatment of human cancers by analyzing the expression of intraflagellar transport (IFT) 20 protein in human ovarian, lung, pancreatic, intestinal, prostate, bone, gastric, and breast cancers.
      Methods  IFT20 protein expression in 8 human cancer tissues was detected by immunohistochemistry.
      Results  IFT20 protein was highly expressed in ovarian cancer tissue, and only lowly expressed in surrounding tissues. IFT20 was expressed moderately in intestinal, gastric, and breast cancer tissues, but lowly in surrounding tissues. IFT20 protein was expressed slightly in bone, pancreatic, and lung cancer tissues. There was no significant IFT20 expression of protein in prostate cancer and surrounding tissues.
      Conclusion  IFT20 can directly or indirectly regulate the initiation and development of ovarian, intestinal, gastric, breast, bone, pancreatic, and lung cancers. Therefore, IFT20 is a potential therapeutic target for cancer treatment.

     

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