Objective  This study was designed to analyze the clinico-pathological features and prognostic factors of uterine papillary serous carcinoma (UPSC) and uterine clear cell carcinoma (UCCC).

  Methods   A retrospective analysis of 41 UPSC patients and 19 UCCC patients who were treated in Tianjin Central Hospital of Gynecology Obstetrics between April 2004 and July 2012 was performed.

  Results   Among the UPSC patients, 24 were subjected to comprehensive surgical staging, which revealed that 9 (37.5%) and 15 (62.5%) patients exhibited early- (only I) and advanced-stage (II1/IV) carcinoma, respectively. For the UCCC patients, 10 were subjected to comprehensive surgical staging, which showed that 6 (60%) and 4 (40%) patients manifested early- (only I) and advanced-stage (IU/IV) carcinoma, re- spectively. Univariate analysis results showed that vascular invasion, positive ascites/peritoneal washing cytology, and lymph node metastasis were the important prognostic factors for overall survival (OS). For disease-free survival (DFS), vascular invasion, myometrial invasion, and positive ascites/peritoneal washing cytology were the important prognostic factors. Multivariate analysis results revealed that vascular invasion and positive ascites/peritoneal washing cytology were the important prognostic factors for OS, whereas positive ascites/peritoneal washing cytology and lymph node metastasis were the important prognostic factors for DFS.

  Conclusions   Poor prognosis of patients was observed when most of them were initially diagnosed with UPSC, particularly when the diagnosis revealed advanced-stage carcinoma. Thus, comprehensive surgical staging is recommended. Furthermore, vascular invasion, myometrial invasion, and lymph node metastasis as well as the result of ascites/peritoneal washings should be considered during prognosis.