Abstract: Genome-wide association studies have revealed a correlation between the hereditary change in the chromosome 8q24 zone and the risk of prostate cancer (PCa). The various single nucleotide polymorphisms are of considerable interest, particularly the rs1447295A/C polymorphism, which has been studied in different populations, including Europeans, Africans, Asians, and their descendants. Large-scale studies have confirmed the remarkably strong association of the rs 1447295A/C polymorphism with the risk of PCa. Recent advances in the relationship between the rs1447295A/C polymorphism in chromosome 8q24 and the risk of PCa were reviewed in this paper.