Abstract: Occult breast carcinoma(occult breast cancer, OBC) is a rare and special type of breast cancer.OBC does show breast mass via clinical examination and imaging studies.Axillary lymph node metastasis or other distant metastases are the first symptoms for OBC; the cancer comes from the breast tissue, as confirmed by pathology.The histopathological examination of the metastatic lymph nodes is the key to the diagnosis of OBC.Enhanced MRI has an important role in indentifying the primary tumor for mammography and ultrasound negative OBC, and contribute to the preoperative occult breast positioning and guiding surgery program.However, surgical treatment for OBC remains controversial.In this study, we introduce one case with advanced metastatic OBC.The successful experience of the multidisciplinary joint diagnosis and individualized comprehensive treatment provide more ideas for the diagnosis and treatment of OBC, emphasizing the multiple disciplinary team treatment model.