结直肠癌腹膜种植转移的相关因素分析

Related factors of peritoneal metastasis in colorectal cancer

    摘要
  • 摘要:
      目的   探讨影响结直肠癌腹膜种植转移的临床病理相关因素。
      方法   收集2005年1月至2009年12月广西医科大学第一附属医院的结直肠癌患者1 170例的临床病理资料, 研究结直肠癌腹膜种植转移与临床病理因素的关系。采用非条件Logistic回归单因素分析, 并对有统计学意义的变量进行非条件Logistic回归多因素分析。
      结果   1 170例结直肠癌患者中, 腹膜种植转移92例(7.86%)。单因素分析显示, 患者的年龄、肿瘤部位、浸润肠腔周径、肿瘤最大径、组织病理学类型、分化程度、肠壁浸润深度、淋巴结转移和血CEA水平与结直肠癌腹膜转移有关。Logistic多因素分析显示, 肿瘤部位、浸润肠腔周径、分化程度、肠壁浸润深度、淋巴结转移和血CEA水平与结直肠癌腹膜转移的有关。
      结论   肿瘤部位、浸润肠腔周径、分化程度、肠壁浸润深度、淋巴结转移和血CEA水平是结直肠癌发生腹膜转移的独立相关因素。

     

    Abstract:
      Objective   This study aims to investigate the clinicopathologic factors related to peritoneal metastasis in 1170 colorectal cancer patients.
      Methods   Clinicopathologic data from 1170 colorectal cancer patients treated in The First Affiliated Hospital, Guangxi Medical University between January 2005 and December 2009 were collected.The associations between peritoneal metastasis and clinicopathological factors were evaluated by univariate and multivariate logistic regression analyses.All analyses were conducted using SPSS software(version 13.0).
      Results   Of the 1170 cases, 92(7.86%) had peritoneal metastases.Univariate analysis showed that age, tumor location, tumor size(cm), tumor circumference, histological type, tumor differentiation, invasion depth, lymph node metastasis, and serum carcinoembryonic antigen(CEA) levels were predictors that could affect peritoneal metastasis.Multivariate analysis showed that tumor location, tumor circumference, tumor differentiation, invasion depth, lymph node metastasis, and serum CEA levels were independent factors related to peritoneal metastasis from colorectal cancer.
      Conclusion   Tumor location, tumor circumference, tumor differentiation, invasion depth, lymph node metastasis, and serum CEA levels were clinicopathologic factors related to peritoneal metastasis from colorectal carcinoma.

     

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