Abstract: Primary liver cancer(PLC) is a malignant tumor with a very high incidence worldwide.Surgery is commonly the treatment of choice for PLC.However, tumor recurrence and metastasis after surgery seriously hamper the long-term efficacy of surgical treatment.The metastasis of hepatocellular carcinoma has long been known to involve a multi-step treatment process.Recent studies have shown that micrometastasis is the cause of tumor recurrence and metastasis.The detection of micrometastasis facilitates the accurate staging of the tumor, treatment, and prognosis.At this writing, markers for detecting liver cancer micrometastasis are available, including telomerase, al pha-fetoprotein mRNA, micro RNAs, E-cadherin, CD44v6mRNA, and cytokeratin.In this study, the researchers reviewed the research progress on the micrometastasis of liver cancer by examining the concept, source of specimen, detection methods, and clinical pathology to investigate the significance of each in the treatment and prognosis of the cancer.