Abstract: The mononuclear macrophage is an important part of the innate immune response of the human body.Macrophages accumulate in tumor tissues, where they become tumor-associated macrophages.MiRNAs are small(22 nt) noncoding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3' untranslated region(3'-UTR) of specific messenger RNAs(mRNAs), resulting in mRNA degradation or translation repression.Many studies have found that miRNAs affect macrophage chemotaxis and differentiation through the regulation of chemokines and inflammatory cytokines.This review summarizes the advances in the research on the effects of microRNAs on the chemotaxis and polarization of tumor-associated macrophages.