Abstract:
Objective This retrospective study aims to determine the efficacy of chemotherapy and improve a salvage chemotherapy agent for metastatic colorectal cancer (MCRC) after failure of treatment with irinotecan and oxaliplatin.
Methods Between January 2002 and March 2013, 37 patients with metastatic MCRC who had progressed after treatment with irinotecan and oxaliplatin were analyzed for their response rate (RR) and progression-free survival (PFS).
Results The overall RR of the 37 patients was 13.51%, with 5 cases of partial response (PR), 12 cases of disease stabilization (SD), and 20 cases of progression (PD). Compared with other chemotherapy regimens, treatment with a pemetrexed-based chemotherapy agent had a higher RR (17.64% vs. 10.00%, P=0.64) without a longer PFS (2.00 months vs. 1.63 months, HR=0.79, 95%, CI: 0.35 to 1.78, P=0.58). Compared with other chemotherapy regimens, treatment with a raltirexed-based chemotherapy agent had a higher RR (16.67% vs. 12.00%, P=0.34) without a longer PFS (1.58 months vs. 1.90 months, HR=2.24, 95%, CI: 0.98 to 5.12, P=0.06).
Conclusion In patients with MCRC after failure of treatment with irinotecan and oxaliplatin, a pemetrexed-based or raltirexed-based chemotherapy agent may beneficial during salvage treatment and is therefore worthy of further study.
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