Objective  Multiple myeloma (MM) complicated with bone marrow amyloidosis was previously reported. In this study, patients with MM complicated with amyloidosis were further analyzed using biochemical markers.

  Methods  A total of 44 patients diagnosed with MM were included in this study. Bone marrow smears stained with Congo red were used and polarized light was utilized to detect MM with amyloidosis. These smears were then divided into two groups: amyloidosis positive and amyloidosis negative. In these groups, blood cell, serum enzyme, and immunoglobulin content were determined. The morphological characteristics of bone marrow cells and the number of immature, mature, and myeloma cells were analyzed.

  Results  The immune marker IgG of the amyloidosis-positive patients with MM was significantly higher than that of the amyloidosis-negative group. Mean kappa and lambda contents decreased. Serum lactate dehydrogenase (LDH) and lactate dehydrogenase 1 (LDH1) activities in the amyloidosis-positive group were significantly higher than those in the amyloidosis-negative group. Significant differences were also observed in several biochemical markers, including PT, Alb, PA, and Glo. Likewise, the index numbers of peripheral blood RBC, WBC, and PLT were significantly different.

  Conclusion  Immunoglobulin content was not correlated with amyloid deposition in patients with MM complicated with bone marrow amyloidosis.