Abstract:
Objective To observe BAG-1, EGFR, and PARP-1 expressions in invasive breast cancer and its correlation with clinical pathological indicators, as well as to evaluate their clinical significance.
Methods The BAG-l, EGFR, and PARP-1 expressions in a tissue microarray of invasive breast cancer and peritumoral tissues were detected through immunohistochemical staining. The clinical and pathological significance of BAG-1, EGFR, and PARP-1 were evaluated.
Results The BAG-1, EGFR, and PARP-1 expression levels are higher in invasive breast cancer tissues than in peritumoral tissues (P < 0.05). BAG-1 expression in invasive cancer tissues is not related to age, tumor site, lymph node metastases, and clinical TNM staging of patients, but is related to size, grade, ER, PR, and HER-2 expressions and molecular subtype (P < 0.05). EGFR expression is related to size, clinical TNM staging, and molecular subtype (P < 0.05). PARP-1 expression is related to grade, lymph node metastases, ER, and molecular subtype (P < 0.05). BAG-1 expression is not significantly correlated with EGFR and PARP-1 in all cases, but BAG-1 and PARP-1 expressions are positively correlated in triple-negative breast cancer tissues (P < 0.05). Results of the univariate analysis revealed that the BAG-1 and PARP-1 expressions and the molecular subtypes are associated with the prognoses of breast cancer patients. Multivariate analysis revealed that BAG-1 and PARP-1 expressions are factors that are independent of the prognosis.
Conclusion BAG-1, EGFR, and PARP-1 overexpressions in human breast tissues suggest that BAG-1, EGFR, and PARP-1 are related to breast cancer development. BAG-1, EGFR, and PARP-1 are potential biomarkers of breast cancer diagnosis and prognosis.