Abstract: Advanced esophageal cancer without distant metastasis remains a potentially curable disease, but the prognosis is poorer in this condition than in the early stage because of a high unresectability rate at presentation and a much higher recurrence rate after radical surgery. The administration of neoadjuvant chemoradiotherapy has several potential benefits for advanced esophageal cancer. This treatment can reduce tumor volume, decrease tumor stage, and improve R0 resection rate; can act on micrometastases, improve local control rate, and improve prognosis; and can evaluate tumor sensitivity to cytotoxic medications. Compared with the increased morbidity and mortality by traditional open procedure, mini-invasive esophagectomy has been associated with less blood loss, reduced postoperative pain, decreased time in the intensive care unit, and shortened length of hospital stay, but with similar long-term prognosis. The current study presents an advanced esophageal cancer patient who underwent neoadjuvant chemoradiotherapy combined with mini-invasive esophagectomy in our hospital. The multimodal treatment achieved a favorable curative effect for the patient. The report aims to promote comprehensive integration of esophageal cancer neoadjuvant therapy and mini-invasive procedure. This study can also enhance interdisciplinary communication and cooperation among medical colleagues in the same fields.