Objective  To evaluate the diagnosis significance of breast mammography assisted by hook-wire localization biopsy for BI-RADS Ⅳ and above negative or non-palpable breast lesions.

  Methods  A total of 48 cases of mammary molybdenum target with BI-RADS Ⅳ level and above but with clinical-touched negative or non-palpable breast lesions (including 4 bilateral lesions and 44 unilateral lesions; total of 52 lesions) were used in the mammography aided by hook-wire localization biopsy.

  Results  Among the 52 lesions, 13 cases were malignant lesions (single), 6 cases were at Stage 0 (accounted for 46.15%), 5 cases were in Stage I (38.46%), and 2 cases were in Stage Ⅱ (15.39%). The remaining 39 cases were benign lesions. Results showed that the detection rate for breast cancer was 25.0%. A total of 39 cases of benign lesions and 10 cases of malignant lesions were found among mammography BI-RADS Ⅳpatients. Zero cases of benign lesions and 3 cases of malignant change were found among BI-RADS Ⅴ patients. The positive rates of breast cancer among BI-RADS Ⅳand Ⅴ patients were 25.64% and 100%, respectively.

  Conclusion  Breast mammography assisted by hook-wire localization biopsy could precisely excise both BI-RADS Ⅳ and Ⅴ negative/non-palpable breast lesions. This technique can also improve the quality of life and prognosis of patients. It is a safe, accurate, and low-cost diagnostic method. Thus, breast mammography assisted by hook-wire localization biopsy must be widely used in clinical applications in China.