肿瘤细胞适应营养缺乏环境的机制及相关研究进展*

齐丽莎, 孙保存

齐丽莎, 孙保存. 肿瘤细胞适应营养缺乏环境的机制及相关研究进展*[J]. 中国肿瘤临床, 2015, 42(9): 478-481. DOI: 10.3969/j.issn.1000-8179.20141663
引用本文: 齐丽莎, 孙保存. 肿瘤细胞适应营养缺乏环境的机制及相关研究进展*[J]. 中国肿瘤临床, 2015, 42(9): 478-481. DOI: 10.3969/j.issn.1000-8179.20141663
Lisha QI, Baocun SUN. Mechanism and research advances regarding adaption of nutrition insufficiency for tumor cells[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(9): 478-481. DOI: 10.3969/j.issn.1000-8179.20141663
Citation: Lisha QI, Baocun SUN. Mechanism and research advances regarding adaption of nutrition insufficiency for tumor cells[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(9): 478-481. DOI: 10.3969/j.issn.1000-8179.20141663

肿瘤细胞适应营养缺乏环境的机制及相关研究进展*

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    通讯作者:

    孙保存

Mechanism and research advances regarding adaption of nutrition insufficiency for tumor cells

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    Corresponding author:

    Baocun SUN;sunbaocun2014@163.com

  • 摘要: 由于具有无限增殖的特点及有氧糖酵解的能量代谢方式,肿瘤细胞对于葡萄糖和谷氨酰胺等营养物质的需求远超过正常细胞,常处于营养缺乏状态。然而,肿瘤细胞可通过某些特定蛋白感知肿瘤微环境中营养物质的供给变化,调控相应的信号通路,阻滞细胞周期、代谢或调节细胞自噬等多种途径适应饥饿状态并不断演进。本综述旨在介绍低营养状态下肿瘤细胞的感知机制、下游效应因子的变化。
    Abstract: Given the unlimited proliferation and aerobic glycolysis in tumor cells, these cells require more glucose, glutamine, and other nutrients compared with normal cells. Tumor cells are often affected by insufficient nutrient supply. However, by sensing changes in the nutrient supply in tumor microenvironment and by regulating signal-transduction pathways, some specific proteins can help tumor cells in blocking the cell cycle, reprogramming metabolism, and regulating autophagy to progress and survive against nutri-ent stress. Exciting innovations have been made to elucidate the mechanisms relevant to this process. This review aims to highlight re -cent studies on the mechanisms of sensing the low nutrient supply in microenvironments, as well as the downstream effect factors in cancer cells.
  • 期刊类型引用(2)

    1. 王一喆,金悦,王晓楠,包博文,程阳,车晓芳,胡雪君. 利用TCGA数据分析果糖二磷酸醛缩酶A对肺癌预后的预测效果. 中国医科大学学报. 2020(07): 586-592 . 百度学术
    2. 汪康,张泊,杜娟,何岸江. 术前免疫肠内营养对结肠癌癌细胞脱落、增殖活性及预后的影响. 结直肠肛门外科. 2017(01): 39-42 . 百度学术

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出版历程
  • 收稿日期:  2014-10-05
  • 修回日期:  2015-04-01
  • 录用日期:  2015-05-14
  • 发布日期:  2015-05-14

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