Abstract: Objective:To investigate the survival and individualized therapy of metastatic colorectal cancer (mCRC) patients who achieved a stable disease state after induction chemotherapy.Methods:Data were reviewed from204 metastatic colorectal cancer pa-tients, who presented a stable disease state after first- line and second- line chemotherapy at Tianjin Medical University Cancer Insti -tute and Hospital. The clinical and pathological characteristics were analyzed. Moreover, we analyzed the significance of maintenance treatment in patients with certain mCRC characteristics. Results:Univariate analysis indicated that the line of chemotherapy, levels of CA724 , CEA, and CA 19- 9, and platelet-to-lymphocyte ratio (PLR) were considered prognostic factors of treatment after induction che -motherapy. According to the multivariate analysis, first-line chemotherapy, as well as low levels of CA19- 9 and PLR, with maintenance treatment after the induction chemotherapy was significantly associated with better survival. Among the patients with high levels of PLR, those who underwent maintenance treatment achieved a progression-free survival of 13. 43months (versus10. 63months in pa-tients from the observation group,P=0. 003 ). Conclusion: The levels of CA19- 9 and PLR, and treatment after chemotherapy were signif -icant prognostic factors for mCRC patients who achieved a stable disease state after induction chemotherapy. These patients, especial-ly those with high PLR, could benefit from the maintenance treatment.