高低级别脑胶质瘤的MRS 代谢产物与Ki-67表达相关性研究*

Correlation of Ki-67expression with MRS metabolism in low- and high-grade cerebral gliomas

  • 摘要: 目的:通过研究明确高低级别脑胶质瘤的磁共振波谱分析(magnetic resonance spectroscopy,MRS )代谢产物与Ki-67表达的关系。方法:选取沈阳军区总医院2013年7 月至2015年7 月病理证实为胶质瘤的56例患者均行Ki-67和MRS 检查;分析Ki-67表达程度与瘤体Cho 值、NAA 值的关系。结果:35例低级别组脑胶质瘤(WHOⅠ~Ⅱ级)Ki-67的表达程度与瘤体Cho 值呈正相关(r s = 0.714,P < 0.05),与瘤体NAA 值呈负相关(r s =-0.708,P < 0.05);21例高级别组脑胶质瘤(WHOⅢ~Ⅳ级)Ki-67的表达程度与瘤体Cho 值呈正相关(r s = 0.624,P < 0.05),Ki-67的表达程度与肿瘤实质NAA 值呈负相关(r s =-0.769,P < 0.05)。 结论:高低级别脑胶质瘤MRS 代谢产物与Ki-67表达相关。

     

    Abstract: objective: To investigate the relationship between magnetic resonance spectroscopy (MRS) metabolism and Ki- 67expres -sion in high- (HGG) and low-grade gliomas (LGG) by analyzing Ki- 67expression and HGG and LGG metabolites. Methods:We consid-ered 56pathologically confirmed glioma cases in our hospital. The Ki- 67expression and the MRS metabolism parameters in the tu-mors were analyzed simultaneously. Results:The tumor solid value of Cho was positively correlated with the Ki-67expression level (rs=0. 714 , P<0. 05). By contrast, the Ki- 67expression level was negatively correlated with the tumor solid value of NAA ( rs=− 0. 708 , P<0. 05) in 35cases of the LGG group. The tumor solid value of Cho was also positively correlated with the Ki-67expression level (rs=0. 624 , P<0. 05). By comparison, the Ki-67expression level was negatively correlated with the tumor solid value of NAA in the HGG group ( rs=−0. 769 , P<0. 05). Conclusion: The MRS metabolism was correlated with the Ki- 67expression in high- and low-grade gliomas.

     

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