Abstract: Colorectal cancer is one of the most common malignancies. Various studies have focused on differences between colon can-cers on the left and right sides. These types of colon cancer differ in terms of their molecular features, embryologic origin, anatomy, pathogenesis to physiological functions, clinical features, treatment response, and prognosis. Therefore, the left- and right-side colon cancers are regarded as different diseases. These differences have significant effect on clinical decision-making and personalized medi -cine.