Abstract: Objective:To explore the effect of family history of cancer on clinical features and prognostic factors in nasopharyngeal car -cinoma (NPC) patients. Methods:The clinical data of 89NPC patients with a family history of cancer and 388 NPC patients without a family history of cancer were retrospectively reviewed. Univariate and multivariate survival analyses were performed to identify possi -ble prognostic factors.Results: The clinical characteristics of NPC patients with and without family history of cancer were compared. The gender, age, TNM stage, pathological type, and hemoglobin radiotherapy concentration before treatment did not significantly dif -fer between the two groups (P>0. 05). NPC patients with a family history of cancer had better 3-year overall survival than those with-out family history of cancer ( 91. 6% vs.85. 5% ), but no statistically significant difference was observed (P=0. 211 ). Both univariate and multivariate analyses showed that T, N, and TNM stages were the important prognosis factors affecting3- year overall survival (OS), progression free survival (PFS), and distant metastasis-free survival (DMFS) of NPC (P<0. 05). However, neither family history of cancer nor family history of NPC in 3- year OS, PFS, LRFS, and DMFS was significant in NPC patients ( P>0. 05). Conclusion: NPC patients with family history of cancer had better 3- year OS than those without family history of cancer, but no statistically significant observation was found. Large T stage or high lymph node stage contributed to poor survival of NPC. Family history of cancer had no significant in-fluence on the survival of NPC patients.