Abstract: Objective:To investigate the factors affecting complete pathological remission in neoadjuvant chemotherapy patients with breast cancer and the influence of complete pathological remission on prognosis.Methods: A total of 267 cases of neoadjuvant chemotherapy patients with breast cancer were selected for this study from January 2008 to December 2014 in our hospital. The clinical and pathological data of the patients were collected. Moreover, the survival of the patients was followed up. Results:Univariate analysis showed that differences in weight, feeding time, cycles of chemotherapy, and tumor size between complete pathological remission and incomplete pathological remission patients subjected to neoadjuvant chemotherapy were statistically significant (P<0.05). The differences in ER, PR, HER 2, and molecular typing between complete pathological remission and incomplete pathological remission patients subjected to neoadjuvant chemotherapy were statistically significant ( P<0.05). Multivariate analysis showed that the weight and ER were independent predictors of complete pathological remission in patients with breast cancer undergoing neoadjuvant chemotherapy (P<0. 05). Survival analysis showed that differences in the disease-free survival and overall survival between complete pathological remission and incomplete pathological remission patients undergoing neoadjuvant chemotherapy were statistically insignificant ( P>0.05). Conclusion: The weight and ER of breast cancer patients in neoadjuvant chemotherapy were independent predictors of complete pathological remission. The complete pathological remission due to neoadjuvant chemotherapy had an insignificant effect on survival.