Abstract: Given that colorectal cancer rarely metastasizes to the brain, only few studies have examined this disease in the past. The incidence of brain metastases increases along with the advances in the comprehensive treatment of such disease and the increased patient survival rates. Several single- center studies have retrospectively reviewed the clinical and pathological characteristics of pa-tients with brain metastases from colorectal cancer and have explored the mechanism and treatment modality of brain metastases. Brain metastases usually occur in the late course of the disease. The primary tumor is frequently localized in the left side of the colon, and most patients have developed metastases in other organs, especially in their lungs. Hematogeneous metastasis is considered the main route of brain metastasis, but its mechanism remains unclear. Early diagnosis depends on the screening of high-risk patients by contrasted MRI. In conclusion, brain metastases from colorectal cancer usually have poor prognosis, and clinicians must comprehen -sively consider the performance status and life expectancy of the patient, the location of the tumor, and the number of metastatic sites to mlake decisions in treatment. Aggressive surgical resection may increase the survival rate of selected patients.