新疆地区食管癌发病风险的病例对照研究

Case-control study of the risk of esophageal cancer in Xinjiang

    摘要
  • 摘要:
      目的  探讨新疆地区食管癌发病的相关因素及特征。
      方法  选取2010年1月至2016年1月经新疆医科大学第一附属医院诊断为食管癌的患者324例为病例组，同期收治的非癌症患者657例为对照组，采用病例对照研究，分析食管癌发病的相关因素及特征。
      结果  2型糖尿病（年限≥2年）为食管癌的相关危险因素，使用胰岛素（≥2年）能够增加食管癌的发病风险。同时吸烟、饮酒、高脂血症、体质量指数≥24、食管憩室为食管癌的危险性因素。
      结论  导致食管癌发病的危险因素较多，目前发现2型糖尿病以及使用胰岛素与食管癌的发生存在一定的关联性，应对糖尿病患者易患食管癌的高危亚群做好一、二级预防。

     

    Abstract:
      Objective  To explore the characteristics of prevailing factors and their influence on esophageal cancer in Xinjiang.
      Methods  Patients diagnosed with esophageal cancer from January 2010 to January 2016 were selected from the Xinjiang Medical University First Affiliated Hospital and categorized as the patient group. Patients without cancer admitted to the same period were classified as the control group. Case control study and correlation analysis between esophageal cancer and type 2 diabetes were performed.
      Results  Type 2 diabetes (≥2 years), as a risk factor, is associated with esophageal cancer. The use of insulin (≥2 years) can increase the risk of esophageal cancer. Smoking, drinking, hyperlipidemia, body mass index≥24, and esophageal diverticulum esophageal cancer are also risk factors.
      Conclusion  The risk factors for esophageal cancer are prevalent among patients with type 2 diabetes patients. Insulin use is also correlated with the occurrence of esophageal cancer. Further studies must be performed to develop secondary prevention for diabetic patients susceptible to esophageal cancer in high-risk subgroups.

     

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