Abstract:
Objective To analyze the clinicopathological features of familial non-medullary thyroid carcinoma (FNMTC).
Methods A retrospective investigation was performed in 24 FNMTC patients from 10 families and 182 sporadic cases who were diagnosed and treated in Tianjin Medical University Cancer Institute and Hospital. Clinicopathological features were analyzed between familial group and sporadic group as well as between the first generation and the later generations of FNMTC patients.
Results Compared with the patients with sporadic cancer, FNMTC patients were more likely to exhibit bilaterality (66.7% vs. 17.0%, P < 0.001), multifocality (45.8%vs. 25.8%, P=0.041), benign nodules (70.8% vs. 40.7%, P=0.005), and central lymph node metastasis (75.0% vs. 35.2%, P < 0.001). The proportion of American Thyroid Association (ATA) high-risk patients with FNMTC was higher than the sporadic group (33.3% vs. 8.8%, P=0.019). Comparison of the disease variants between the first generation and the later generations in FNMTC group showed that the latter were presented with disease at an earlier age at the time of diagnosis (mean 45.6±10.3 vs. 35.3±5.4, P=0.031).
Conclusion Bilaterality, multifocality, presence of benign nodules, and central lymph node metastasis are special features of FNMTC. Moreover, the second generation has a younger age at the time of diagnosis compared with the first generation of FNMTC patients.
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