结直肠癌中微卫星不稳定性与PD-L1表达的关系及临床意义

Relationship between expression of PD-L1 and microsatellite instability of colorectal cancer and its significance

    摘要
  • 摘要:
      目的  研究PD-L1在结直肠癌(colorectal cancer, CRC)中的表达及临床意义.
      方法  选取2015年1月至2016年1月在郑州大学附属肿瘤医院接受CRC根治性手术的患者210例，分为微卫星高度不稳定（high-frequency microsatellite instability，MSI-H）、微卫星低度不稳定（low-frequency microsatellite instability，MSI-L）、微卫星稳定（microsatellite stable，MSS）3个组，采用免疫组织化学法检测各组织标本中细胞程序性死亡配体1（Programmed cell death 1 ligand 1，PD-L1）的表达，分析PD-L1在各型CRC中的表达特点。
      结果  PD-L1在低分化CRC中的表达高于中、高分化CRC（P＜0.05），PD-L1在MSI-H的CRC中阳性率为75.8%，在MSIL/MSS中的阳性率为9.3%，两组比较差异具有统计学意义（P＜0.05）。
      结论  PD-L1在部分CRC癌组织中阳性表达，尤其是在MSIH的CRC阳性率显著高于MSI-L及MSS的CRC。PD-L1阻断剂对MSI-H的CRC患者疗效可能更好。

     

    Abstract:
      Objective  To investigate the expression and clinical significance of PD-L1 in colorectal cancer(CRC).
      Methods  A total of210 CRC patients who accepted radical surgery in our hospital from January 2015 to January 2016 were divided into three groups, namely, high-frequency microsatellite instability(MSI-H), low-frequency microsatellite instability(MSI-L), and microsatellite stable(MSS).The expression of PD-L1 was detected by immunohistochemistry, and the expression characteristics of PD-L1 in different typesof CRC were analyzed.
      Results  CRC cases with low differentiation had a higher expression of PD-L1 than CRC patients with high differentiation(P < 0.05).PD-L1 had a positive rate of 75.8% in the MSI-H group and a rate of 9.3% in the MSI-L and MSS groups, wherein thedifference between the two groups was statistically significant(P < 0.05).
      Conclusion  D-L1 was positively expressed in some CRC tumor tissues, and its positive rate was significantly higher in MSI-H than in MSI-L and MSS.The therapeutic effect of a PD-L1 blocker forpatients with MSI-H CRC might be preferable.

     

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