双表型肝细胞癌新亚型的临床病理学研究进展

Research progress on clinicopathology in dual-phenotype hepatocellular carcinoma

摘要: 双表型肝细胞癌（dual-phenotype hepatocellular carcinoma，DPHCC）是近年报道的肝细胞癌（hepatocellular carcinoma，HCC）的一种新亚型，以组织学上为典型的肝细胞癌但同时表达肝细胞癌和肝内胆管癌（intrahepatic cholangiocarcinoma，ICC）的基因标志物为特征，因其具有HCC和ICC的双重生物学行为，恶性程度更高，临床预后差，因而正确诊断十分重要。CK19是DPHCC诊断的重要标志物之一，可以通过多种途径参与DPHCC的发生和恶性生物学行为的调控。本文拟从DPHCC的临床病理特点、免疫组织化学标记、组织起源发生等方面对DPHCC的研究进展进行综述。

Abstract: Dual-phenotype hepatocellular carcinoma (DPHCC) is a novel subtype of hepatocellular carcinoma (HCC). DPHCC presents the classical morphology of HCC but simultaneously expresses the biomarkers of HCC and intrahepatic cholangiocarcinoma (ICC). Accurate diagnosis of DPHCC is necessary because of its combined biological behaviors of HCC and ICC, highly malignant degree, and infaust clinical prognosis. CK19 is an important marker of DPHCC and regulates the clonal origin and biological behavior of DPHCC in various pathways. In this paper, we reviewed the research progress of DPHCC focusing mainly on its clinicopathological features, immunohistochemical biomarkers, and histogenesis.