个体化经肛提肌外腹会阴联合切除术治疗低位直肠后壁肿瘤对盆底影响的有限元分析

Finite element analysis of the effects of individual extralevator abdominoperineal excision of rectal neoplasms in the low posterior wall on the pelvic floor

  • 摘要:
      目的  应用有限元分析方法探讨个体化经肛提肌外腹会阴联合切除术(extralevator abdominoperineal excision,ELAPE)治疗低位直肠后壁肿瘤对术后盆底生物力学的影响。
      方法  利用MIMICS 10.01、GeoMagic Studio 12及ANSYS Workbench 14.0软件,分析2014年7月至2015年1月于天津医科大学肿瘤医院招募的27例健康未育女性志愿者的盆底核磁共振数据并建立3种盆底有限元模型:正常模型、ELAPE模型和个体化ELAPE模型,测量3种模型在相同载荷作用下非肛提肌组织内的最大应力及正常模型与个体化ELAPE模型肛提肌内的最大应力,并观察应力分布。
      结果  正常模型、ELAPE模型和个体化ELAPE模型的非肛提肌组织内最大应力分别为(1.963±0.061)、(5.127±0.070)、(3.667±0.126)MPa(均P < 0.01),三者的高应力区均出现在盆底左右两侧与骨盆内侧壁的连接处,最大应力均出现在左右两侧最前端与耻骨连接处;正常模型与个体化ELAPE模型的肛提肌内最大应力分别为(0.812±0.042)、(1.437±0.043)MPa(P < 0.01),二者的高应力区均出现在左右两侧与肛提肌腱弓连接处的前部,最大应力均出现在左右两侧最前端与耻骨连接处。
      结论  本研究采用的个体化ELAPE术对于盆底非肛提肌组织内的应力有降低作用。

     

    Abstract:
      Objective  To evaluate the effects of individual extralevator abdominoperineal excision(ELAPE)of rectal neoplasms in thelow posterior wall on the pelvic floor by finite element analysis.
      Methods  MIMICS 10.01, Geo Magic Studio 12, and ANSYS Workbench14.0 were used to analyze the magnetic resonance data obtained from the pelvic region of 27 healthy nulliparous volunteers.Threetypes of finite element models(intact model, ELAPE model, and individual ELAPE model)were developed.The maximal stress on nonlevator ani tissues were analyzed using the three models, while the maximal stress on levator ani tissues were analyzed using the intact model and the individual ELAPE model.Their stress distributions under the same pressure were analyzed and compared.
      Results  The maximal stress on non levator ani tissues obtained using the intact model, ELAPE model, and individual ELAPE model were(1.963±0.061), (5.127±0.070), and(3.667±0.126)MPa, respectively, with P < 0.01.High-stress zones were obtained at the joints with pelvicwalls on both sides using the three models, while the maximal stresses were obtained at the joints with pubis on both sides.The maximal stress on levator ani tissues obtained using the intact model and individual ELAPE model were(0.812±0.042)MPa and(1.437±0.043)MPa, respectively.Thus, the individual ELAPE model yielded higher values of maximal stress compared to the intact model.Both models generated high-stress zones at the joints with tendinous arch of levator ani tissues on both sides, and maximum stressesat the joints with pubis on both sides.
      Conclusion  Individual ELAPE decreases the stress on non levator ani tissues.This suggests thatthe risk of postoperative pelvic floor hernia is relatively reduced.

     

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