Abstract: Progress in the treatment of gastric cancer (GC) is a major concern because GC is a common cancer worldwide. Recently, by studying the molecular mechanisms of GC, researchers learned that GC progression involved a series of changes at the molecular level, including the activation of signaling pathways, abnormal expression and mutation of genes, and response to related targeted drugs used in clinics. However, many targeted drugs produce resistance in a short period of time because of complicated cellular, microenvironmental, and genetic instabilities. Therefore, it is important to find new targets against GC. In this review, we present the current research status and progress with respect to GC targets.