Abstract: As a common primary intracranial tumor, malignant glioma accounts for 81% of all central nervous system malignancies. After standard treatment, such as surgery combined with external radiotherapy and chemotherapy, glioblastoma patients' survival is only 14.4 months. Hence, the traditional treatment is difficult to meet patients' needs of survival and life quality. In recent years, chlorogenic acid (CGA), as plant extract polyphenols, has received widespread attention. Its antitumor properties, through its effects on the immune system, anti-oxidation properties, cell cycle regulation, and inhibition of tumor cell metastasis and invasion, have been extensively studied. This article will discuss the mechanisms involved in glioma treatment, synergism with other drugs, and metabolism in the human body, to provide a reference for the application of CGA in the treatment of the condition.