Abstract: Pancreatic cancer (PC) is a highly malignant disease. Significant fibrosis and tumor heterogeneity are important characteristics of PC that have been attributed to the poor chemotherapeutic response and poor prognosis of patients with PC. Therefore, it is imperative to develop more effective treatment strategies to improve the survival rate of PC patients. In order to improve the response rates and accuracy of treatment for PC, domestic and foreign scholars have directed their efforts in elucidating the mechanisms of tumor microenvironment that mediate PC development to identify more effective treatment strategies targeting this microenvironment. This paper reviews the latest advances and therapeutic strategies for targeting the tumor microenvironment, under the concept of precise treatment, and also provides a new idea for further improving the survival rates of patients with PC.