Abstract:
Objective To investigate the relationship between aberrant crypt foci (ACF) and colorectal cancer through a 2-year followup colonoscopy observation of patients with ACF.
Methods We enrolled 100 patients who accepted colonoscopies from January 2013 to December 2014 in The Second Hospital of Shanxi Medical University. The patients did not have common carcinogenic or cancer-suppressing factors and agreed to participate in the study. Routine rectal indigo carmine staining was carried out, and we observed and recorded the number of ACFs and the natural development process of single ACFs at the baseline, the 1st year, the 2nd year using colonoscopies.
Results There was no statistical difference in ACF positive incidence among baseline, 1st year, and 2nd year exams. During the 2-year observation, most ACFs remained or disappeared, and only a few developed into polyps or adenomas, which were common in subjects with ≥6 ACFs; while those with oval crypt openings mostly died away.
Conclusions ACFs are heterogeneous, and only a subset of ACFs may be biomarkers for colorectal cancer.
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