Abstract: Due to the several complex anatomical and functional subunits in the head and neck (H&N) area, early and precise diagnosis with an accurately targeted treatment for H&N tumors is very important to cure the disease and improve overall survival. Radiomics is noninvasive and uses an image information processing technique to transform qualitative and quantitative information from clinical images and clinical data. Radiomics can be used in several stages of H&N tumor diagnosis and treatment, including H&N cancer staging, radiation dose calculations, radiotherapy related side effects, tumor delineation, assessing cervical lymph nodes, and for predicting tumor prognosis and HPV (human papilloma virus) infection status in patients with H&N squamous cell carcinoma. Radiomics has vast potential and can effectively contribute to clinical decision-making and treatment management.