Abstract: Stereotactic body radiation therapy (SBRT) is a high-precision radiotherapy technology that provides high-dose and highprecision radiotherapy through less fractional irradiation. SBRT can significantly improve local control and survival rates in patients with hepatocellular carcinoma (HCC). SBRT can also be an effective and safe bridging therapy for patients awaiting liver transplantation. Moreover, recent studies have reported the potential effects of the combination of SBRT and immune checkpoint inhibitors. This article reviews the safety and efficacy of SBRT in the treatment of HCC, in anticipation of the future application of SBRT in combination with immunotherapy.