局部T晚期与N晚期鼻咽癌患者的预后比较

Comparison of the prognosis of advanced T and N stage in patients with nasopharyngeal carcinoma

    摘要
  • 摘要:
      目的  回顾性分析局部T晚期与N晚期鼻咽癌患者的预后情况，为临床鼻咽癌治疗提供参考。
      方法  选取2011年12月至2017年11月西部战区总医院经病理确诊为鼻咽癌的局部T晚期患者102例、局部N晚期患者162例的临床病例资料，分为两组并分析患者的预后情况。
      结果  局部T晚期与N晚期患者5年总生存率（overall survival，OS）分别为82.8%与75.8%（P=0.271）、无疾病进展生存率（progression-free survival，PFS）分别为73.7%与62.8%（P=0.043），无局部复发生存率（local relapse-free survival，LRFS）分别为87.6%与91.6%（P=0.646）、无远处转移生存率（distant metastasis-free survival，DMFS）分别为87.7%与79.5%（P=0.066），两组间PFS差异具有统计学意义。
      结论  局部N晚期鼻咽癌患者的DMFS、OS、PFS均有下降趋势，临床上局部N晚期鼻咽癌患者应更强调系统性治疗以及分层治疗的意义，以争取更高的OS并降低远处转移。

     

    Abstract:
      Objective   To retrospectively compare the prognosis between patients with locally advanced T and N stage nasopharyngeal carcinoma (NPC), to provide a reference for the clinical treatment of NPC.
      Methods  A total of 264 NPC cases from December 2011 to November 2017 visiting The General Hospital of Western Theater Command were pathologically diagnosed and retrospectively analyzed. Of these, 102 and 162 were locally advanced T and N stage, respectively.
      Results  The two groups 5-year overall survival (OS), progression-free survival (PFS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) were compared. These were 82.8% and 75.8% (P=0.271), 73.7% and 62.8% (P=0.043), 87.6% and 91.6% (P=0.646), 87.7% and 79.5% (P=0.066), respectively.
      Conclusions  The DMFS, OS and PFS decreased in patients with locally advanced N stage NPC, although there was no statistical difference. The significance of systemic and stratified treatment should be emphasized in patients with locally advanced N stage NPC in order to achieve a higher OS rate and reduce distant metastasis.

     

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