Abstract: Recurrence and metastasis are crucial clinical events leading to mortality in patients with lung cancer. The overall efficiency of prevention and control of lung cancer metastasis needs to be improved. The breakthrough in advanced lung cancer treatment achieved by immune-targeted therapy based on regulation of adaptive immunity fully confirms the clinical importance of immune editing in clinical guidance. However, there is still a lack of high-level clinical evidence for prevention and treatment of distant metastasis after early radical surgery, suggesting that lung cancer metastasis may have an alternative mechanism other than adaptive immunity. Therefore, this review focuses on the relationship between innate immune disorder and occurrence of distant metastasis. We further discuss the interaction between tumor cells and various innate immune cells such as NK cells, macrophages, neutrophils and dendritic cells, as well as the clinical applications of innate immune cell regulation in the prevention and treatment of lung cancer metastasis, including the role of innate immune cells as biomarkers to enrich the metastasis evaluation system. It links innate immune disorder to lung cancer metastasis and puts forward the theory of "hidden toxicity due to vital qi deficiency, " facilitating the establishment of a specific research platform to explore the interaction between immune cells and tumor cells for identifying key targets for the prevention and treatment of lung cancer metastasis and to develop comprehensive immunotherapy to improve the prevention and control efficiency of lung cancer metastasis.