保留乳头乳晕复合体乳腺癌根治术的肿瘤学风险及适应证

The Oncologic Risks and Indications for Nipple-areola Complex Sparing Mastectomy

  • 摘要: 保留乳头乳晕复合体(nipple-areola complex,NAC)的乳腺癌改良根治术是在保留胸肌的改良根治术的基础上,进一步保留乳头、乳晕,其具有保乳手术良好的效果,同时又达到改良根治术的较低的复发率,可望作为Ⅰ、Ⅱ期乳腺癌手术治疗的常规选择术式。该术式的缺陷在于保留NAC带来的残留癌的风险,因此术前结合NAC浸润相关因素,准确预测NAC受累风险,从而制定恰当的手术适应证是关键。本文就保留NAC的乳腺癌改良根治术的肿瘤学风险及适应证进行综述。

     

    Abstract: Nipple-areola complex sparing mastectomy is an improved surgical procedure that preserves the nip-ple-areola complex (NAC). This procedure is based on modified radical mastectomy techniques that retain thepectoralis major and minor. Theoretically, this surgical procedure achieves a favorable aesthetic and it en-sures a lower recurrence rate compared with breast-conservation surgery (BCS). NAC sparing mastectomy isrecommended for stage I and stage II breast cancer patients, especially for Asian women who have relativelysmall breasts. However, tumor invasion into the NAC has been an obstacle for the feasibility of NAC sparingmastectomy. Preserving the NAC carries a high risk of residual carcinoma remaining. It is necessary to pre-dict and estimate the risk of NAC involvement in breast cancer patients before surgery. Independent predic-tors including mammographic distance, pathologic stage, and tumor size were identified in patients with NACinvolvement. In this article we review the oncologic risks of and indications for NAC sparing mastectomy.

     

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