Abstract: Objective: To assess the value of a computer-aided detection (CAD) software in detection of breast cancer. Methods: A total of 226 patients with breast cancer conformed histologically from December 2004 to May 2005 were collected.All of them underwent full-field digital mammography (FFDM). Four methods were used in detecting breast cancer: CAD software alone, inexperienced radiologists with and without the CAD software and experienced radiologists alone. Chi-square test was applied to analyze the data. Results: (1) No statistical significance was found in detecting breast cancer,masses (MA) and microcalcifications (MC) between CAD software and the inexperienced radiologists(P=0.3061, P=0.5063,P=0.4215). (2) There were significant differences in the detection of breast cancer, MA and MC between the CAD and the experienced radiologists (P=0.0000, P=0.0000, P=0.0002). (3) The detection rates of breast cancer, MA, MC were signifi-cantly increased after implementation, respectively (P=0.001 1, P=0.0000, P=0.0001). The detection rates of MC were in-creased more than that of MA (MC, from 80.23% to 98.84%; MA, from 85.65% to 96.76%). (4) There were no significant differences in the detection of MA and MC between the inexperienced radiologist with the CAD software and the experi-enced radiologists(P=0.153 6, P=0.092 1, P=0.315 9). Conclusion: CAD software showed a potential value to assist the in-experienced radiologists in detecting breast cancer.