儿童和青少年甲状腺癌的临床特点和治疗(附59例报告)

Clinical Features and Therapeutic strategy of Thyroid Carcinoma in Children and Adolescents

  • 摘要: 目的: 观察儿童和青少年甲状腺癌复发和淋巴结转移的影响因素及远期预后,并探讨其治疗。 方法: 1970-1987年于我院住院治疗的59例儿童和青少年甲状腺癌患者(≤20岁),其中行腺叶切除术12例、患侧腺叶切除加气管食管沟淋巴结清除术8例、腺叶切除加颈淋巴结清除术39例。术后均行内分泌治疗。 结果: 术后随访20年,20年生存率为91.53%。34例患者(57.63%)发生颈淋巴结转移,12例(20.34%)术后肿瘤复发。肿瘤侵犯被膜、双侧腺体受累者易发生颈淋巴结转移、术后肿瘤复发,年龄≤15岁者易发生术后肿瘤复发。cN0患者中甲状腺叶切除术与甲状腺叶切除+气管食管沟淋巴结清除术相比、cN+患者中功能性与根治性颈淋巴结清除术相比,术后肿瘤复发率未见统计学差异(P>0.05)。 结论: 儿童和青少年甲状腺癌的治疗应分层细化和注重保护功能。

     

    Abstract: Objective: To analyze the recurrence-related factors, metastasis-related factors, long-term prognosis and therapeu-tic strategy of thyroid carcinoma in children and adolescents. Methods: Data from 59 children and adolescents(≤20) with thyroid carcinoma seen in our hospital between 1970 and 1987 were evaluated. Of these 59 patients, 12 underwent lobec-tomy, 8 underwent lobectomy and central compartment node clearance, and 39 underwent lobectomy and neck dissection.Thyroid hormone suppressive therapy was administered to all patients after surgery. Results: The 20-year survival rate was 91.53%. Thirty-two patients(57.63%) had cervical lymph node metastasis, and 12 patients(20.34%) had local recur-rence after surgery. Capsule invasion and bilateral involvement were correlated with tumor recurrence and lymph node metastases. Age≤15 was correlated with tumor recurrence. For cN0 patients, no significant difference was found in tumor recurrence rate between patients treated with lobectomy and those treated with lobectomy plus central compartment node clearance. For cN+ patients, no statistical significance was found in tumor recurrence rate between patients treated with functional neck dissection and those treated with radical neck dissection (P>0.05). Conclusion: The treatment for thyroid carcinoma in children and adolescents should be based on careful stratification of low-and high-risk cases and special at-tention should be paid to protectiong normal function.

     

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