Abstract: Objective : To discuss the clinical value of an integrated surgical procedure in preventing early postopera-tive complications of pancreaticoduodenectomy. Methods : In the past 6 years, data from 113 patients who un-derwent pancreaticoduodenectomy were divided into two groups according to the surgical procedure they re-ceived. Thirty-six patients received the integrated surgical procedure (Group A). Seventy-seven patients un-derwent other types of procedures (Group B). We compared gender, age, preoperative albumin level, durationof surgery, blood loss, postoperative hospital stay, days in ICU, incidence of postoperative complications andmortality between the two groups. Results : In Group A, 7 (19.4%) patients had early postoperative complica-tions such as pancreatic fistula, biliary fistula, hemorrhage and abdominal infection, and 1 of them died. InGroup B, 45 patients developed early postoperative complications and 38 of them had two or more types ofcomplications. Five patients in Group B died (6.5%). Compared to Group B, Group A had a shorter postopera-tive hospital stay and a lower incidence of pancreatic fistula and intraperitoneal infection ( P <0.05). No signifi-cant difference was found in surgical duration, blood loss, days in ICU, biliary fistula, and mortality betweenthe two groups ( P >0.05). Conclusion : The integrated surgical procedure is an ideal method to prevent earlypostoperative complications of pancreaticoduodenectomy and to decrease the postoperative hospital stay.