Abstract: Objective : To evaluate the clinical value of the combination of¹⁸F-FDG SPECT and ^99MTC-MDP bonescan in the follow-up monitoring of cancer recurrences of breast cancer patients previously treated with bothmastectomy and chemotherapy. Methods : A total of 81 female breast cancer patients who had received mas-tectomy and chemotherapy within the past three years were enrolled in this study. All of them underwent¹⁸F-FDG SPECT, ^99MTC-MDP bone scan and CT. The calculations of the sensitivity, specificity, and accuracywere analyzed. Results : Thirty-one patients who had cancer recurrences (local, regional and distant recur-rences) were identified by pathology or other examinations. The sensitivity, specificity, and accuracy of¹⁸F-FDG SPECT in diagnosing breast cancer recurrences (local, regional and distant recurrences) were74.2%, 92.0%, and 85.2%, respectively. The sensitivity, specificity, and accuracy of CT in the detection of can-cer recurrences were 58.1%, 88.0%, and 76.5%, respectively. The sensitivity, specificity, and accuracy of thecombination of¹⁸F-FDG and ^99M TC-MDP in the diagnosis of cancer recurrences were 93.5%, 92.0%, and92.6%, respectively. Conclusion : The combination of¹⁸F-FDG and ^99MTC-MDP for breast cancer patients pre-viously treated with both mastectomy and chemotherapy has a higher sensitivity, specificity and accuracy.