适形放疗联合介入治疗宫颈癌放疗后盆腔复发的临床观察

Effects of Three-Dimensional Conformal Radiotherapy Combined with Interventional Chemotherapy for Recurrent Cervical Cancer

  • 摘要: 目的: 评价三维适形放疗联合介入治疗复发性宫颈癌的近期疗效和毒副反应。 方法: 分析放疗后盆腔复发宫颈患者癌27例,给予动脉介入治疗两周期后,复发病灶适形放疗50~55Gy。 结果: 1年生存率为59.2%,CR22.2%,PR59.3%,总有效率(CR+PR)为81.5%,症状缓解率:腰骶疼痛71.4%(15/21),下肢痛64.3%(9/14),下肢水肿40%(2/5)。急性Ⅲ度以上膀胱、直肠反应、骨髓抑制发生率分别为14.8%、18.5%、25.9%,1例发生晚期放射性膀胱炎,2例出现晚期放射性直肠炎,盆腔皮下组织纤维化3例,全组未发生治疗相关性死亡。 结论: 三维适形放疗联合介入治疗宫颈癌放疗后盆腔复发,近期疗效满意,毒副反应可以接受,远期疗效仍需进一步观察。

     

    Abstract: Objective : To evaluate the effects of three-dimensional conformal radiotherapy combined with interven-tional chemotherapy on recurrent cervical carcinoma. Methods : Thirty-one patients with recurrent cervical car-cinoma infiltrating the pelvic wall were treated by two courses of interventional chemotherapy followed bythree-dimensional conformal radiotherapy with a total dose of 50~55Gy. Results : The overall 1-year-survivalrate was 59.2%. The total response rate was 81.5%. The remission rates of lumbosacral area pain, inferior ex-tremity pain and leg edema were 71.4%, 64.3% and 40%, respectively. No treatment related death occured. Conclusion : Three-dimensional conformal radiotherapy combined with interventional chemotherapy has goodeffects on both short-term survival and symptom relief for patients with recurrent cervical carcinoma. The ad-verse events were tolerable but the long-term benefits of this treatment method warrant further study.

     

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