Abstract:
Objective : To investigate the characteristics of lung sarcomatoid carcinoma (LSC) and to analyze the cor-responding prognostic factors.
Methods : We retrospectively reviewed the clinical data from 47 patients withLSC seen in our hospital from September 1985 to July 2007. Forty-four of them underwent surgery and the re-maining 3 patients received non-surgical therapy. Gender, age, smoking history, tumor size, p-TNM stage,and histological type were analyzed. The survival rate was calculated by Kaplan-Meier method and log-ranktest was used to compare the survival rates. Univariate and multivariate factors for survival were analyzed byCox proportional hazards regression model.
Results : The clinical characteristics of LSC were similar to thoseof other types of lung cancer. The overall 1-, 3-, and 5-year survival rates were 59.6%, 27.7% and 8.5%, re-spectively. Cox univariate analysis revealed that age, tumor size, p-TNM stage, T stage, lymph node metasta-sis, M stage and histological type were prognostic factors. Cox multivariate analysis found that age, T stage,and M stage were independent prognostic factors for LSC.
Conclusion : There is no specificity in the clinicalcharacteristics of LSC and its successful diagnosis depends on postoperative pathological analysis. Age, Tand M stage are the crucial prognostic factors for LSC.