两性腺原发性淋巴瘤26例临床病理分析

Clinicopathologic Analysis of 26 Cases of Primary Malignant Lymphoma of the Testis or Ovary

  • 摘要: 目的: 探讨发生在睾丸、卵巢的原发性淋巴瘤的临床病理形态特点、临床分期和预后的关系。 方法: 对21例原发性睾丸恶性淋巴瘤、5例卵巢原发性恶性淋巴瘤进行组织形态学和免疫组织化学染色观察,依据WHO新分类进行分型,Ann Arber(1971)国际分期法进行临床分期并结合文献对其临床病理特点及随访资料进行分析。 结果: 睾丸恶性淋巴瘤平均好发于60~70岁,随访21例患者中,弥漫大B细胞性淋巴瘤13例,中位生存期35.2个月,5年生存率38.5%;T细胞性淋巴瘤5例,中位生存期18.6个月,2年生存率40.0%,无5年生存率。B小淋巴细胞性淋巴瘤1例及淋巴浆细胞样淋巴瘤2例,5年生存率100%。就诊时病程处于Ⅰ期8例,中位生存期75.1个月。Ⅱ期8例,中位生存期36.5个月。Ⅲ、Ⅳ期5例,中位生存期8个月。卵巢原发性恶性淋巴瘤少见,病情进展迅速预后差。本组5例均为B细胞性淋巴瘤,其中小淋巴细胞性3例,淋巴浆细胞样淋巴瘤2例,Ⅰ期1例,Ⅱ期2例,Ⅲ期2例,其中2例失访,随诊3例均于1年内死亡。 结论: 睾丸原发性恶性淋巴瘤预后与临床分期、组织学分型关系密切,术后放、化疗有利于提高患者生存率,卵巢原发性恶性淋巴瘤预后差。

     

    Abstract: Objective: To observe the clinicopathologic characteristics of primary malignant lymphoma of the testisor ovary. Methods: Samples from 26 cases of primary malignant lymphoma in the testis or ovary were observed with HEstain and immunohistochemistry. The lymphomas were classified according to the WHO (2001) critieria. We used Ann Ar-ber to identify the clinical stages. Results: There were 21 cases of primary testicular non-Hodgkin's lymphoma (rangedfrom 60 to 70 years). For the 13 cases of diffuse large B-cell lymphoma, the median survival was 35.2 months and the 5-year survival rate was 38.5%. For the five cases of T cell lymphoma, the median survival was 18.6 months, the 2-year sur-vival rate was 40.0% and the 5-year survival rate was 0%. For the one case of B-SLL and two cases of lymphoplasmacy-toid lymphoma, the 5-year survival rate was 100%. The median survival was 75.1 months for the eihgt stage Ⅰ cases,36.5 months for the 8 stage Ⅱ cases, and eihgt months for the five stage Ⅲ and stage Ⅳ cases. There were five cases ofprimary malignant lymphoma in the ovary and were all diagnosed as B-cell lymphoma(thee cases of B-small lymphocyticlymphoma and two cases of lymphoplasmacytoid lymphoma). There were one stage Ⅰ case, two stage Ⅱ cases and twostage Ⅲ cases. Three patients died within 1-7 months and the follow-up data of the other two patients were unavailable. Conclusion: Most of the testicular primary malignant lymphomas are DLBCL. The prognosis is correlated with the initialstage of disease and morphological characteristics. The prognosis of ovarian primary malignant lymphoma is worse.

     

/

返回文章
返回